منابع مشابه
Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients
Tumor profiling of DNA alterations, i.e. gene point mutations, somatic copy number aberrations (CNAs) and structural variants (SVs), improves insight into the molecular pathology of cancer and clinical outcome. Here, associations between genomic aberrations and disease recurrence in stage II and III colon cancers were investigated. A series of 114 stage II and III microsatellite stable colon ca...
متن کاملAdjuvant Systemic Therapy in Stage II and III Colon Cancer
The prognosis of colon cancer is primarily determined through staging of the disease. After curative surgery, clinically occult micrometastases are thought to be the major source of disease recurrence. The main aim of postoperative systemic treatment is to eradicate micrometastases, thereby improving outcomes with an increased cure rate. Adjuvant systemic chemotherapy is indicated for patients ...
متن کاملInfluence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers.
Lymph node (LN) harvest is influenced by several factors, including tumor genetics. Microsatellite instability (MSI) is associated with improved node harvest, but the association to other genetic factors is largely unknown. Research methods included a prospective series of stage I-III colon cancer patients undergoing ex vivo sentinel-node sampling. The presence of MSI, KRAS mutations in codons ...
متن کاملCDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.
Background The identification of high-risk stage II colon cancers is key to the selection of patients who require adjuvant treatment after surgery. Microarray-based multigene-expression signatures derived from stem cells and progenitor cells hold promise, but they are difficult to use in clinical practice. Methods We used a new bioinformatics approach to search for biomarkers of colon epithelia...
متن کاملImmunoscore® as a predictor of response to chemotherapy in stage II and stage III colon cancer
Background No biomarker has been validated so far to predict the need for adjuvant chemotherapy in Stage II colon cancer (CC), and current guidelines, e.g. NCCN, only rely on the identification of high-risk features such as MSI, pathological tumor characteristics or expected chemotherapy efficacy/safety ratio in each individual patient. In contrast, adjuvant chemotherapy is recommended for all ...
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ژورنال
عنوان ژورنال: Archives of Surgery
سال: 2000
ISSN: 0004-0010
DOI: 10.1001/archsurg.135.2.182